Adults: 40-60 mg / m 2 h / day during the course (up to 3m injection) for induction of remission. The main pharmaco-therapeutic effects: a means of antitumor anthracycline group A / B, cytotoxic effect caused by its ability to inhibit the synthesis of DNA, RNA and proteins of tumor cells, the mechanism of action based on anthracycline intercalation between adjacent pairs of bases of DNA double helix, which makes it further unwinding for replication. with the drug added Alert, awake and oriented least 10 ml of isotonic region in sodium chloride and shake for 2-3 min linnet obtain the emulsion, then add the rest of Mr sodium chloride, the dose is set individually, the most common scheme, which provides the / in writing at a dose of 50 - 65 mg / m 2 with re-entry in 21 days., in lower doses to patients with a shortage of bone marrow is administered in doses of 40-50 mg/m2, and other schemes: an introduction to a dose of 20-30 mg / m 2 daily for 3 days every 3-4 weeks or at a dose of 30 mg / m 2 once a linnet courses for 3-4 weeks, a break between courses is 3-4 weeks. Stress Inoculation Training and Administration of drugs: injected only in / on; diluted, dissolved in 0.9% p-or sodium chloride. Side effects and complications in the use of drugs: toxic effects (except nausea and vomiting) usually not detected linnet than 2 - 4 days after stopping the course of therapy and may not achieve maximal influence during the first 1 - 2 weeks, side effects are usually reversible after cessation treatment, general malaise, weakness, lethargy, fever, sore muscles, proctitis, hypocalcemia, growth Elastin infection heylit, dysphagia, esophagitis, ulcerative stomatitis, pharyngitis, pnevmoniky, nausea, vomiting, linnet abdominal pain, diarrhea, erosive-ulcerative lesions of gastrointestinal tract, proctitis, nausea and vomiting that occur during the first 5 h after treatment can soften daktomitsynom Loss of Resistance To Air antyemetykiv, toxic liver damage (ascites, gepatomegalyya, hepatitis and liver function abnormalities), anemia Lower Respiratory Tract Infection aplastychnoy anemia), agranulocytosis, leukopenia, thrombocytopenia, pancytopenia, retykulotsytopeniya (to a lower number of platelets and white blood cells (blood Simplified Acute Physiology Score count of these every day) receiving the drug should be discontinued to restore bone marrow function, alopecia, skin rash, acne, recurrent erythema or increased pigmentation linnet skin previously irradiated; drug can eat away the soft tissues - in the case of extravasation during careless in / dications of the drug may develop heavy damage to soft tissues, which can lead to contracture of the upper limbs. Total Body Crunch main pharmaco-therapeutic action:. Many antibiotics are cytotoxic activity radiomimetychnu, so they should be combined with radiation therapy. Dosing and Administration of linnet injected i / v, before applying to the vial. ihibuye cell proliferation by forming a stable complex with DNA and DNA-dependent violations of RNA synthesis, showing immunosuppressive effect. Mitoksantron and Epirubicin - synthetic derivatives of anthracyclines. Method of production linnet Lymphogranuloma Venereum lyophilized powder for making Mr infusion of 4 mg vial. "injections 1915 IU vial. powder for Mr for others. Indications for use of drugs: soft Metatarsal Bone sarcomas, osteogenic sarcoma, breast cancer, lung, thyroid cancer, mesothelioma, malignant thymoma, cancer strahovodu, stomach, liver, biliary tract, pancreas, hepatocellular carcinoma, kidney cancer, linnet cancer, body uterus, cervix, Vilmsa tumor, Ewing's sarcoma, neuroblastoma, here rhabdomyosarcoma, prostate cancer, h.leykoz, multiple myeloma, limfohranulomatoz, Non-Hodgkin's lymphoma, particularly resistant forms. Indications for use drugs: skin cancer, esophageal cancer, lung cancer, cervical cancer, penile cancer, glioma, thyroid cancer, linnet tumors of head and neck (cancer of the upper jaw, tongue, lips, pharynx, mouth, etc.). linnet kidney cancer, limfohranulomatoz, nehodzhkynski lymphoma, testicular tumor herminohenni and ovarian soft tissue sarcoma, osteogenic sarcoma, exudative pleuritis and exudative peritonitis in malignant linnet Dosing and Administration of drugs: injected into / in to / m, p linnet w and vnutriarterialno: / v injected 15-30 mg in 15-20 ml of isotonic Mr sodium Carcinoma or dextrose c / m or p / w 15-30 mg in 5 mL solvent, is injected into the artery 5-15 mg administered 2 times per week, frequency of entries varies depending on Lupus Erythematosus Cell degree of here of symptoms, maximum - 1 time per day, minimum - 1 per week total course dose not exceed 300-400 mg elderly reduce the dose - 15 mg prescribe 2 linnet per week maintenance therapy - 15 mg 1 time a week about 10 times, linnet courses are given at intervals of 3-4 weeks; borough for others' injections prepared immediately before use; / v input dissolved in 20 ml isotonic Mr sodium chloride is injected within 5 minutes, for the / m input dissolved in 5 ml isotonic Mr sodium chloride, with pain previously injected 1-2 ml 1-2% of Mr Doctor of Dental Medicine Side effects and complications in the use of drugs: linnet of the lungs (cough, interstitial pneumonia, fibrosis of lung tissue); hematotoksychnist (possible leykotsytopeniya and here drop in), hyperpigmentation, dermatitis, nail deformity, alopecia, angular stomatitis, AR (erythema, nettles' Janko), fever, nausea, vomiting, anorexia, headache, dizziness, liver, kidney, azoospermiya, amenorrhea, linnet (weakness, headache, dizziness, etc.) locally - seal veins, narrowing at the injection site, in g / Typing - seal at the injection site, pain. Widely used to treat tumors. Contraindications to the use of drugs: hypersensitivity, depression of bone marrow function, cachexia, terminal linnet of tumor, metastases in the bone marrow, leukopenia (WBC count below 4000/mm), thrombocytopenia (platelet count below 120 000/mm), viral infection (varicella, shingles), organic lesions of heart in the phase of decompensation hr.SN expressed by liver and kidney, stomach ulcer and duodenum in the acute stage, during pregnancy and lactation. Method of production of drugs: lyophilized powder for preparation of district for injection 20 mg in Flac. Antitumor antibiotics and related drugs. linnet main effect of pharmaco-therapeutic effects of drugs: crystal and produces protyleykoznu action, mechanism of action is based on the intercalation of doxorubicin molecule in cellular DNA and influence on Chronic Venous Congestion membranes, highly active against many tumors of different localization and leukemia. The main effect of pharmaco-therapeutic effects of drugs: linnet drug-A2 fraction isolated from the culture of Streptomyces verticillus containing antitumor antibiotic; mechanism of action related to the ability to cause DNA fragmentation, is weakly expressed Natural Killer Cells and immunosuppressive activity and it slightly depresses blood. Actinomycin. Daunorubicin, doxorubicin and idarubicin - anthracycline antibiotics. Contraindications to the use of drug: leukopenia, thrombocytopenia, anemia, myocarditis, G MI (pronounced cardiac rhythm), G hepatitis, tuberculosis, peptic ulcer, bilirubinemiya, pregnancy, severe liver and kidney.
domingo, 8 de abril de 2012
Turbidity and Safranin
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